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    Some patients developed severe joint pain again when they restarted the same medicine or another DPP-4 inhibitor.We urge health care professionals and patients to report side effects involving DPP-4 inhibitors to the FDA MedWatch program, using the information in the “Contact FDA” box at the bottom of the page.Table 1. In 22 cases, symptoms appeared within 1 month of initiation of treatment with a DPP-4 inhibitor. American Heart Association Science Volunteer Warning Signs Search for this keyword Search Advanced Search Donate . Home About this JournalGeneral Statistics Editorial Board Editors Information for Advertisers Author Reprints Commercial Reprints Customer Service and Ordering Information All Issues SubjectsAll Subjects Arrhythmia and Electrophysiology Basic, Translational, and Clinical Research Critical Care and Resuscitation Epidemiology, Lifestyle, and Prevention Genetics Heart Failure and Cardiac Disease Hypertension Imaging and Diagnostic Testing Intervention, Surgery, Transplantation Quality and Outcomes Stroke Vascular Disease Browse FeaturesAHA Guidelines and Statements Acknowledgment of Reviewers Clinical Implications Clinical-Pathological Conferences Controversies in Hypertension Editors' Picks Guidelines Debate Meeting Abstracts Recent Advances in Hypertension SPRINT Trial: the Conversation Continues ResourcesInstructions to Reviewers Instructions for Authors Article Types Submission GuidelinesResearch GuidelinesMinimum Information About Microarray Data Experiments (MIAME) Abstract Acknowledgments Clinical Implications (Only by invitation) Conflict(s) of Interest/Disclosure(s) Statement Figure Legends Figures Novelty and Significance: 1) What Is New, 2) What Is Relevant? References Sources of Funding Tables Text Title Page Online/Data Supplement Tips for Easier Manuscript Submission General Instructions for Revised ManuscriptsChange of Authorship Form Costs to Authors Open Access, Repositories, & Author Rights Q&A Permissions to Reprint Figures and Tables Journal Policies Council on Hypertension Council on the Kidney in Cardiovascular Disease (KCVD) AHA Journals RSS Feeds International Users AHA Newsroom AHA JournalsAHA Journals Home Arteriosclerosis, Thrombosis, and Vascular Biology (ATVB) Circulation Circ: Arrhythmia and Electrophysiology Circ: Cardiovascular Genetics Circ: Cardiovascular Imaging Circ: Cardiovascular Interventions Circ: Cardiovascular Quality & Outcomes Circ: Heart Failure Circulation Research Hypertension Stroke Journal of the American Heart Association Facebook Twitter My alerts Sign In Join Search for this keyword Search Advanced search Header Publisher Menu American Heart Association Science Volunteer Warning Signs Advanced Search Donate . Search for this keyword Advanced Search . Some patients had a recurrence of severe joint pain when restarted on either their original DPP-4 inhibitor medication or another DPP-4 inhibitor.Consider DPP-4 inhibitors as a possible cause for any patient who presents with severe and persistent joint pain, and consider discontinuation of therapy with this class of drugs.Encourage patients to read the Medication Guide they receive with their DPP-4 inhibitor prescriptions.Report adverse events involving DPP-4 inhibitors to the FDA MedWatch program, using the information in the "Contact FDA" box at the bottom of this page.Data SummaryIn a search of the FDA Adverse Event Reporting System (FAERS) database, we identified 33 cases of severe arthralgia reported with the use of dipeptidyl peptidase-4 (DPP-4) inhibitors from October 16, 2006, approval date of the first DPP-4 inhibitor, through December 31, 2013. .. Each case involved the use of one or more DPP-4 inhibitor. All 33 patients experienced arthralgia that resulted in a substantial reduction in their prior level of activity, including 10 patients who were hospitalized due to disabling joint pain. Note: Most addresses are also case sensitive. Food and Drug Administration (FDA) is warning that the type 2 diabetes medicines sitagliptin, saxagliptin, linagliptin, and alogliptin may cause joint pain that can be severe and disabling. These medicines are available as single-ingredient products and in combination with other diabetes medicines such as metformin (see Table 1 below).In a search of the FDA Adverse Event Reporting System (FAERS) database and the medical literature,1-4 we identified cases of severe joint pain associated with the use of DPP-4 inhibitors. Drug Safety Communication (PDF - 70KB).

     

    Home CurrentCurrent Issue Online Ahead of Print Standards of Medical Care Browse By Collection Issue Archive Special Collections Recent ADA Position Statements InfoAbout the Journal Meet the Editors Reprints & Permissions Journal Policies For Authors For Advertisers SubscriptionsManage Online Access Individual Subscriptions Institutional Subscriptions AlertsE-mail Alerts RSS Feeds PodcastsDiabetes Core Update Diabetes Discovery SubmitJournal Policies Instructions for Authors Submit a Manuscript .. Rheumatol Int 2014;34:291-2.Yokota K, Igaki N. In six cases, patients had partial or complete resolution of symptoms within 6 weeks of discontinuing the drug. Acute onset of rheumatoid arthritis associated with administration of a dipeptidyl peptidase-4 (DPP-4) inhibitor to patients with diabetes mellitus. If you clicked on a link, there may be a problem with that link. Sitagliptin (DPP-4 inhibitor)-induced rheumatoid arthritis in type 2 diabetes mellitus: a case report. Main menu Home CurrentCurrent Issue Online Ahead of Print Standards of Medical Care Browse By Collection Issue Archive Special Collections Recent ADA Position Statements InfoAbout the Journal Meet the Editors Reprints & Permissions Journal Policies For Authors For Advertisers SubscriptionsManage Online Access Individual Subscriptions Institutional Subscriptions AlertsE-mail Alerts RSS Feeds PodcastsDiabetes Core Update Diabetes Discovery SubmitJournal Policies Instructions for Authors Submit a Manuscript More from ADADiabetes Clinical Diabetes Diabetes Spectrum Standards of Medical Care Scientific Sessions Abstracts BMJ Open Diabetes Research & Care User menu Subscribe Log in Search Search for this keyword Advanced search . DPP4 inhibitor-induced polyarthritis: a report of three cases. The time to onset of symptoms following initiation of drug therapy varied from 1 day to years. 19d25c4272

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